Study on Chlorella Vulgaris and Sarcopenia

WHAT IS SARCOPENIA?

Sarcopenia is described by the loss of tissue mass, energy, and capacity with aging. With rising life expectancy, more substantial regard has been provided for inhibiting the impacts of sarcopenia on the growing elderly community. A drop in the performance of biological functions is seen with the progress of aging. Several organs and systems, such as the digestive system, nervous system, and cardiovascular system, are altered by aging. In the muscular-skeletal system, a consequent decline of skeletal muscle mass, energy, and capacity are observed with progressing age. This condition is known as sarcopenia.

Sarcopenia has been defined as an age-related drop of muscle mass, service, and durability, with high predominance after aging. Although sarcopenia exhibits in older individuals, the causes of this disease are multifactorial. They include alterations in the body, such as chronic illness, inflammation, and insulin immunity, in addition to environmental circumstances like nutritional insufficiencies, bed comfort, and physical inactivity. Skeletal muscle produces energy for the support of body temperature, stores protein supplies, and maintains body position, while also strengthening and protecting soft tissues.

The adverse impacts of sarcopenia include a drop in the number of motor assemblies and muscle fiber size and a rise in muscle fiber atrophy. Nevertheless, other factors such as diet, hormones, metabolism, immunological health, and a stationary lifestyle can also head to a reduction in muscle mass and strength. These cases increased abnormal movements, impaired oxidative metabolism, poor glucose management, vulnerability, loss of independence, reduced mobility, falls and splits, and, ultimately, morbidity and mortality.

CHLORELLA AS TREATMENT

Chlorella vulgaris, a tiny green alga with the potential for several medical applications, has been broadly examined in some researches. This specific study aimed at defining the effects of C. vulgaris on improving muscle recovery by evaluating myoblast regenerative capacity in vitro.

Cultured human skeletal myoblast cells had undergone serial passaging into immature and senescent stages and were then manipulated with C. vulgaris, accompanied by the induction of differentiation. The capability of C. vulgaris to improve myoblast differentiation was examined through cellular morphology, real-time monitoring, cell reproduction, senescence-associated β-galactosidase (SA-β-gal) expression, myogenic differentiation, myogenin diagnosis, and cell sequence profiling.

CONCLUSION

C. vulgaris enhances the regenerative capability of young and senescent myoblasts and improves myoblast differentiation, showing its potential to develop muscle recovery. The human skeletal myoblast cells utilized in the study can generate up to a specific number of reproduction doublings and then lose their ability to proliferate upon moving replicative or cellular senescence. Cells were held young through the first one-third of their lifespan and senescent at the end of their lifespan. After which cells left to generate even with reworked feeding.

Cell cycle characterizations indicate the state of cellular generation and the effect of C. vulgaris on myoblast differentiation. C. vulgaris has been proclaimed on beforehand due to its possible action as an antiageing factor by reducing the expression of aging biomarkers in senescent human diploid fibroblasts.

source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589273/