Chlorella Vulgaris and Liver Enzymes


Fatty liver happens when extremely many fats form up in liver cells. Although it is reasonable to have a small amount of fat in these cells, the liver is estimated to be fatty if more than 5% of it is fat. There are two distinct types of nonalcoholic fatty liver illness:

Simple fatty liver: This implies that you possess fat in your liver, but you may not have any swelling in your liver or injury to your liver cells. It usually doesn’t get more severe or create problems with your liver. Most personalities with NAFLD have mild fatty liver.

Nonalcoholic steatohepatitis (NASH): This is hugely more serious than a simple fatty liver. NASH suggests you have inflammation in your liver. The swelling and liver cell destruction that occur with NASH can generate serious illnesses such as fibrosis and cirrhosis, which are signs of liver scarring, and liver cancer.


Chlorella – unicellular green microalgae- is famous as a functional diet and alternative medication worldwide, especially in Asia. It is utilized as a nutritional supplement because of producing a high volume of amino acids apart from methionine and tyrosine, minerals, vitamins, fiber, and bioactive aggregates. Several studies have published particular advantageous physiological results toward oxidation, cataract, bacterial and viral disease, and swelling as well as weight loss, hypoglycemic and hypocholesterolemic impacts in mammals.

Non-alcoholic fatty liver disease (NAFLD) is shifting into a public health dilemma worldwide, and utilizing microalgae is a current plan for its treatment. Lee et al. reported that chlorella containing nutrition raised the total volume of excreted feces and lipids and consequently, reduced liver and serum total lipids, triglycerides (TG) and total cholesterol (TC) without any vital decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) applications in animals.

Certainly, C. vulgaris may be helpful for the prevention of dyslipidemia. Supplementation with C. vulgaris reduced weight, ALT, AST, and TG levels in NAFLD cases.


This research has contributed insights into the weight loss outcome of C. vulgaris supplementation with NAFLD patients. In the present study, significant losses were observed in ALT and ALP levels in both groups, and AST decreased in C. vulgaris group. Although limited studies are examining the impact of chlorella on liver function, Lee et al. had considered different nutrition intake comprising 5% and 10% w/ chlorella matched with a diet without chlorella on liver proteins in rats and discovered that ALT and AST levels did not alter after consumption of chlorella-containing foods.

Indeed, C. vulgaris consumption has proclaimed enhancing the hepatic degeneration of cholesterol by up-regulation of the interpretation of Cholesterol 7α hydroxylase. C. vulgaris supplement carries niacin as a reputed medicine for hyperlipidemia in each time as well as Omega-3 fatty acids, which may be liable for the hypotriglyceridemic impacts of this microalgae.

Many mechanisms for hypoglycemic effects of C. vulgaris have been suggested, i.e., decrease in plasma NEFA concentration which enhances glucose uptake, glucose utilization, improves the elimination of hepatic glucose generation, as well as activation of insulin signaling pathways, effects from variations in gene expression in the peripheral blood cells, are the potential mechanisms.